AFP mRNA Detected in Bone Marrow by Real-Time Quantitative RT-PCR Analysis Predicts Survival and Recurrence After Curative Hepatectomy for Hepatocellular Carcinoma

摘要

Hepatocellular carcinoma cells were perioperatively detected by real-time quantitative RT-PCR targeting AFP mRNA in bone marrow and peripheral blood of HCC patients who underwent curative hepatectomy. Positive AFP mRNA correlated significantly with portal vein invasion. AFP mRNA in bone marrow predicts patient survival and recurrence after curative hepatectomy for HCC.